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In the bottom right of this high power image, we can also see a portion of the underlying zona reticularis. Moving deeper into the adrenal gland, the zona fasciculata is the largest of the three zones and comprises about 65 to 80 percent of the cortex. These are the cells that are responsible for secreting aldosterone into nearby capillaries that can be found throughout this layer. The individual cells are either columnar or pyramidal with round nuclei, and a lipid-filled cytoplasm that gives the cytoplasm its pale “foamy” appearance.

The secretory cells are arranged in ovoid or glomerulus-like clusters that are separated by fibrous trabeculae that extends from the capsule. This layer is just beneath the capsule and comprises about 15 percent of the cortex. Now, let’s take a closer look at the outermost layer of the adrenal cortex, the zona glomerulosa. Just outside of the capsule, there are small afferent blood vessels that are branches of the suprarenal arteries that supply blood to the adrenal gland.Īnd within the medulla, there are the large medullary veins that drain blood into the suprarenal veins. If we zoom in further, we can see some of the blood vessels of the adrenal gland. The medulla is responsible for secreting the catecholamines: epinephrine and norepinephrine. The adrenal medulla is the region that’s most centrally located and visibly distinct from the cortex.

Starting with the most superficial zone: the zona glomerulosa secretes mineralocorticoids, the zona fasciculata secretes primarily glucocorticoids, and the zona reticularis secretes primarily gonadocorticoids, or sex hormones.

The cortex can be further divided into three zones that each secrete a different class of steroid hormones. The cortex is the large outer region of the adrenal gland. The parenchymal tissue has two main regions, the adrenal cortex and the adrenal medulla. The adrenal glands are covered by a capsule made of thick connective tissue.

The left gland has a semilunar shape and the right gland is flattened and more triangular in appearance. The adrenal glands are a pair of endocrine glands that are located just above or superior to the kidneys and are also in the retroperitoneal space of the abdominal cavity.